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FLLL-32
CAS No. 1226895-15-3
FLLL-32 ( JAK2 Inhibitor X | FLLL32 )
产品货号. M10870 CAS No. 1226895-15-3
FLLL-32 是姜黄素的细胞渗透性类似物，可抑制癌细胞中 JAK2 介导的 Tyr705 上 STAT3 的磷酸化 (IC50=5 uM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥715 | 有现货 |
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| 10MG | ￥946 | 有现货 |
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| 25MG | ￥1730 | 有现货 |
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| 50MG | ￥2678 | 有现货 |
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| 100MG | ￥3717 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥758 | 有现货 |
|
生物学信息
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产品名称FLLL-32
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述FLLL-32 是姜黄素的细胞渗透性类似物，可抑制癌细胞中 JAK2 介导的 Tyr705 上 STAT3 的磷酸化 (IC50=5 uM)。
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产品描述FLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM); induces apoptosis in pancreatic and breast cancer cell lines; also inhibit colony formation in soft agar and cell invasion and exhibits synergy with Doxorubicin against breast cancer cells; decreases STAT3 DNA binding activity and expression, and induces apoptosis in several cancer cell lines.
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体外实验FLLL32 specifically reduces STAT3 phosphorylation at Tyr705 (pSTAT3) and induces apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures.
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体内实验——
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同义词JAK2 Inhibitor X | FLLL32
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通路JAK/STAT Signaling
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靶点STAT
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受体JAK2
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研究领域Cancer
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适应症——
化学信息
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CAS Number1226895-15-3
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分子量464.6
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分子式C28H32O6
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纯度>98% (HPLC)
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溶解度DMSO: 85 mg/mL (183 mM); Ethanol: 24 mg/mL (51.7 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(C1(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)CCCCC1)/C=C/C3=CC=C(OC)C(OC)=C3
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化学全称(2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)]-2-propen-1-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lin L, et al. Cancer Res. 2010 Mar 15;70(6):2445-54.
2. Bill MA, et al. Mol Cancer. 2010 Jun 25;9:165.
3. Fossey SL, et al. BMC Cancer. 2011 Mar 28;11:112.
