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Calphostin C
CAS No. 121263-19-2
Calphostin C ( UCN 1028C | PKF115-584 )
产品货号. M10793 CAS No. 121263-19-2
一种有效的、选择性的、光依赖性 PKC 抑制剂，IC50 为 50 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Calphostin C
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种有效的、选择性的、光依赖性 PKC 抑制剂，IC50 为 50 nM。
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产品描述A potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM; displays >1,000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase; inhibits cell growth and promotes apoptosis in HeLa S3 and MCF-7 cells with IC50 of 0.23 and 0.18 uM, respectively; also inhibits phospholipase D1 and D2 (IC50=100 nM); also blocks β-catenin/Tcf transcriptional activity.Solid Tumors Discontinued.
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体外实验——
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体内实验——
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同义词UCN 1028C | PKF115-584
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通路Angiogenesis
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靶点PKC
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受体PKC
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研究领域Cancer
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适应症Solid Tumors
化学信息
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CAS Number121263-19-2
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分子量790.76
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分子式C44H38O14
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(CC1=C2C3=C(C(=C(C4=C3C(=C5C2=C(C(=O)C=C5OC)C(=C1OC)O)C(=CC4=O)OC)O)OC)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC(=O)C7=CC=CC=C7
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化学全称1-(4,9-dihydroxy-12-(2-(((4-hydroxyphenoxy)carbonyl)oxy)propyl)-2,6,7,11-tetramethoxy-3,10-dioxo-3,10-dihydroperylen-1-yl)propan-2-yl benzoate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Solamargine
Solamargine 是从中药 Solanum nigrum L. (SNL) 中提取的主要甾体生物碱苷；已被证明可以抑制多种癌细胞的生长并诱导其凋亡。
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PKC β pseudosubstrat...
Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.
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PKC412
Midostaurin (PKC412; CGP 41251) 是一种具有口服活性的可逆多靶点蛋白激酶抑制剂。Midostaurin 抑制 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ 和 VEGFR1/2，IC50 范围为 22-500 nM。Midostaurin 还上调内皮一氧化氮合酶 (eNOS) 基因表达。Midostaurin 显示出强大的抗癌作用。
