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Duvelisib
CAS No. 1201438-56-3
Duvelisib ( IPI-145 | INK-1197 )
产品货号. M10723 CAS No. 1201438-56-3
一种有效的选择性 PI3Kδ/γ 抑制剂，Ki 为 23 pM/243 pM，IC50 为 1 nM/50 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥466 | 有现货 |
|
| 5MG | ￥724 | 有现货 |
|
| 10MG | ￥1017 | 有现货 |
|
| 25MG | ￥1693 | 有现货 |
|
| 50MG | ￥2539 | 有现货 |
|
| 100MG | ￥3582 | 有现货 |
|
| 200MG | ￥5103 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥663 | 有现货 |
|
生物学信息
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产品名称Duvelisib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种有效的选择性 PI3Kδ/γ 抑制剂，Ki 为 23 pM/243 pM，IC50 为 1 nM/50 nM。
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产品描述A potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM; displays high selectivity for PI3K δ/γ than other protein kinases; exerts profound effects on adaptive and innate immunity by inhibiting B and T cell proliferation, blocking neutrophil migration, and inhibiting basophil activation; exhibits potent activity in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models.Blood Cancer Phase 3 Clinical.
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体外实验PI3Kδ and PI3Kγ inhibition with Duvelisib (IPI-145) has anti-proliferative activity in primary AML cells by inhibiting the activity of AKT and MAPK. Pre-treatment of AML cells with Duvelisib inhibits both adhesion and migration of AML blasts to bone marrow stromal cells.
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体内实验——
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同义词IPI-145 | INK-1197
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通路PI3K/Akt/mTOR signaling
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靶点PI3K
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受体PI3Kα|PI3Kβ|PI3Kγ|PI3Kδ
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number1201438-56-3
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分子量416.863
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分子式C22H17ClN6O
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 41 mg/mL
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SMILESO=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)C)=CC5=C1C(Cl)=CC=C5
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化学全称1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Winkler DG, et al. Chem Biol. 2013 Nov 21;20(11):1364-74.
2. Boyle DL, et al. J Pharmacol Exp Ther. 2014 Feb;348(2):271-80.
3. Dong S, et al. Blood. 2014 Dec 4;124(24):3583-6.
产品手册
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