A-967079

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的选择性 TRPA1 通道阻断剂，hTRPA1 和 rTRPA1 的 IC50 分别为 51 nM 和 101 nM。

A potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively; displays >1,000-fold selective over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes, and G-protein-coupled receptors; exhibits analgesic efficacy in allyl isothiocyanate-induced nocifensive response and osteoarthritic pain in rats (ED50=23.2 mg/kg), attenuates cold allodynia produced by nerve injury but does not alter noxious cold sensation in naive animals; orally bioavailable.Pain Preclinical

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A967079 | A 967079

Membrane Transporter/Ion Channel

TRP/TRPV Channel

TRP/TRPV Channel

Neurological Disease

Pain

1170613-55-4

207.24

C12H14FNO

>98% (HPLC)

DMS : 100 mg/mL482.53 mM;H2O : < 0.1 mg/mL

CCC(/C(C)=C/C1=CC=C(F)C=C1)=N\O

(1E,3E)-1-(4-fluorophenyl)-2-methylpent-1-en-3-one oxime

(-20℃)

With Ice Pack

≥ 2 years