NSC 370284

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NSC 370284 是一种小分子，可直接结合并抑制 STAT3/5，在体外和体内均显着且选择性地抑制高水平 TET1 表达的 AML 细胞的活力。

NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.

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Animal Model:C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice.Dosage:2.5?mg/kg.Administration:Intraperitoneal injection, once daily, for 10 days.Result:Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice.

NSC370284

JAK/STAT Signaling

STAT

STAT

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116409-29-1

387.432

C21H25NO6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (258.11 mM)

COC1=CC(=CC(=C1OC)OC)C(C2=CC3=C(C=C2O)OCO3)N4CCCC4

6-(pyrrolidin-1-yl(3,4,5-trimethoxyphenyl)methyl)benzo[d][1,3]dioxol-5-ol

(-20℃)

With Ice Pack

≥ 2 years