J147

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

J-147 是一种广谱神经保护苯酰肼化合物 (EC50=60-115 nM)，具有与诱导脑源性神经营养因子 (BDNF) 相关的显着神经营养特性。

J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).(In Vitro):J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06-0.115 μM) .(In Vivo):J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice.The half life (t1/2) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg).

——

Animal Model:24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controlsDosage:200 ppmAdministration:The diet was prepared by the addition of 200ppm; 6 monthsResult:While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with J147.

J147 | J 147 | J-147

Chromatin/Epigenetic

Epigenetic Reader Domain

BDNF

Neurological Disease

——

1146963-51-0

350.34

C18H17F3N2O2

>98% (HPLC)

Soluble in DMSO

O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC)=C2)C(F)(F)F

2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

(-20℃)

With Ice Pack

≥ 2 years