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UCN-01
CAS No. 112953-11-4
UCN-01 ( 7-Hydroxystaurosporine | NSC 638850 )
产品货号. M10455 CAS No. 112953-11-4
UCN-01（7-Hydroxystaurosporine；NSC 638850）是 staurosporine 的合成衍生物，对多种体外和体内癌症模型具有抗增殖活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称UCN-01
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述UCN-01（7-Hydroxystaurosporine；NSC 638850）是 staurosporine 的合成衍生物，对多种体外和体内癌症模型具有抗增殖活性。
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产品描述UCN-01 (7-Hydroxystaurosporine;NSC 638850) is a synthetic derivative of staurosporine that has antiproliferative activity against several in vitro and in vivo cancer models; inhibits a variety of kinases, including Akt, PKC (IC50=30 nM), PDK1 (IC50=6 nM), CDKs (IC50=300-600 nM for Cdk1 and Cdk2); arrests tumor cells in the G1/S phase of the cell cycle and prevents nucleotide excision repair by Chk1 (IC50=7 nM); induces apoptosis.
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体外实验——
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体内实验——
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同义词7-Hydroxystaurosporine | NSC 638850
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通路Angiogenesis
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靶点PKC
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受体PKC
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研究领域——
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适应症——
化学信息
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CAS Number112953-11-4
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分子量482.5
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分子式C28H26N4O4
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C[C@@H](O)C=C12)C1=C3C4=CN=CC4=C5C6=C3N2C/C=C\[C@@](O7)(C)[C@@H](OC)[N@@]6(NC)C8=C5C=C[C@@]7([H])C8
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化学全称(3R,9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kawabe T. Mol Cancer Ther. 2004 Apr;3(4):513-9.
2. Peifer C, et al. ChemMedChem. 2008 Dec;3(12):1810-38.
3. Facchinetti MM, et al. Cancer Res. 2004 May 15;64(10):3629-37.
产品手册
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