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Amcasertib
CAS No. 1129403-56-0
Amcasertib ( BBI-503 )
产品货号. M10454 CAS No. 1129403-56-0
一种小分子抑制剂，通过靶向激酶来抑制 Nanog 和其他 CSC（癌症干细胞）途径。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥933 | 有现货 |
|
| 10MG | ￥1596 | 有现货 |
|
| 25MG | ￥3283 | 有现货 |
|
| 50MG | ￥4827 | 有现货 |
|
| 100MG | ￥6597 | 有现货 |
|
| 500MG | ￥13140 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Amcasertib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种小分子抑制剂，通过靶向激酶来抑制 Nanog 和其他 CSC（癌症干细胞）途径。
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产品描述A small-molecule inhibitor that inhibits Nanog and other CSC (cancer stem cells) pathways by targeting kinases; targets and inhibits one or more pathways involved in cancer stem cell survival, shows potential antineoplastic activity.Liver Cancer Phase 2 Clinical(In Vitro):Amcasertib (0-1μM; 48h) inhibits the NANOG and CD133 expression in PC-9/GR cells. Amcasertib also significantly suppresses the growth of PC-9/GR cells in a dose-dependent manner.
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体外实验Amcasertib (0-1μM; 48h) inhibits the NANOG and CD133 expression in PC-9/GR cells. Amcasertib also significantly suppresses the growth of PC-9/GR cells in a dose-dependent manner. Cell Viability Assay Cell Line:PC-9/GR cell Concentration:0, 0.3125, 0.625, 1.25, 2.5, 5 and 10μM Incubation Time:48 hours Result:Suppressed the growth of PC-9/GR cells in a dose-dependent manner for 48?hours with a OD value decreased from over 1.5 to less than 0.2 (p体内实验——同义词BBI-503通路Others靶点Other Targets受体Others研究领域Cancer适应症Liver Cancer
化学信息
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CAS Number1129403-56-0
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分子量539.691
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分子式C31H33N5O2S
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 30 mg/mL
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SMILESO=C(C1=C(C)NC(/C=C2C(NC3=C/2C=C(C4=CSC(C5=CC=CC=C5)=N4)C=C3)=O)=C1C)NCCN(CC)CC
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化学全称1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[[1,2-dihydro-2-oxo-5-(2-phenyl-4-thiazolyl)-3H-indol-3-ylidene]methyl]-2,4-dimethyl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Marcucci F, et al. Front Oncol. 2016 May 10;6:115. 2. Iv Santaliz-Ruiz LE, et al. Int J Cancer. 2014 Dec 15;135(12):2741-8.
