021-51111890
购物车（）
sales@molnova.cn
KBFM123
CAS No. 1090346-46-5
KBFM123 ( KBFM-123 )
产品货号. M10342 CAS No. 1090346-46-5
KBFM123 (KBFM-123) 是 GTP 结合形式的 H-Ras 的小分子变构抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称KBFM123
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述KBFM123 (KBFM-123) 是 GTP 结合形式的 H-Ras 的小分子变构抑制剂。
-
产品描述KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras, weakly inhibits the association of H-RasG12V-GppNHp with c-Raf-1 RBD (Kd=10-100 uM); interacts directly with a hydrophobic pocket located between Switch I and Switch II and allosterically inhibits the effector interaction by inducing conformational changes in Switch I and its flanking region in the β2-strand, which are directly involved in recognition of the effector molecules including c-Raf-1; KBFM123 is a promising scaffold for the development of Ras inhibitors.
-
体外实验——
-
体内实验——
-
同义词KBFM-123
-
通路MAPK/ERK Signaling
-
靶点Ras
-
受体Ras
-
研究领域——
-
适应症——
化学信息
-
CAS Number1090346-46-5
-
分子量271.316
-
分子式C16H17NO3
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESC1CC(OC1)CNC(=O)C2=CC3=CC=CC=C3C=C2O
-
化学全称3-hydroxy-N-((tetrahydrofuran-2-yl)methyl)-2-naphthamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Matsumoto S, et al. Biochemistry. 2018 Aug 24. doi: 10.1021/acs.biochem.8b00680.
