G-418 disulfate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种氨基糖苷类抗生素，结构与庆大霉素B1相似；通过抑制原核和真核细胞中的延伸步骤来阻断多肽合成。

An aminoglycoside antibiotic similar in structure to gentamicin B1; blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.(In Vitro):G418 sulfate, an aminoglycoside neomycin analogue, interferes with protein synthesis and has been used extensively for selection of mammalian cell lines that possess neomycin resistance (NR). The neomycin resistance (neo) gene is frequently used in eukaryotic vectors as a dominant selectable gene. G418 can be covalently bound to asialoorosomucoid (AsOR) to form a conjugate for hepatocyte-specific targeting and toxicity.The human GD3 synthase cDNA was transfected into MDA-MB231 cells, and G-418 bulk selection was used to select cells stably overexpressing the GD3 synthase. An aminoglycoside antibiotic, G418, has been shown to be an inhibitor of many pro- and eukaryotes at concentrations from 1-300 microgram/ml.

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Geneticin sulfate

GPCR/G Protein

Antibacterial

Others

Other Indications

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108321-42-2

692.7094

C20H44N4O18S2

>98% (HPLC)

H2O: ≥ 30 mg/mL

O[C@@H]1[C@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](C(O)C)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@](O)(C)[C@H]1NC.O=S(O)(O)=O

D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-α-D-gluco-heptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-, sulfate (1:2)

(-20℃)

With Ice Pack

≥ 2 years