Clinafloxacin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Clinafloxacin (PD-127391) 是一种氟喹诺酮类抗生素。

Clinafloxacin(PD-127391) is a fluoroquinolone antibiotic.

Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants.Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of?S. aureus. It against Wild type S. aureus, gyrA?mutant S. aureus and gyrA?mutant S. aureus with MIC values of 0.016 μg/ml, 0.063 μg/ml and 0.915 μg/ml, respectively.

Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model.With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis.

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GPCR/G Protein

Antibacterial

Antibacterial

Infection

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105956-97-6

365.79

C17H17ClFN3O3

>98% (HPLC)

DMSO: 0.03 mg/mL (0.08 mM)

NC1CCN(C1)C1=C(F)C=C2C(=O)C(=CN(C3CC3)C2=C1Cl)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years