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PKC beta II inhibitor H6
CAS No. 1046787-18-1
PKC beta II inhibitor H6 ( —— )
产品货号. M10233 CAS No. 1046787-18-1
PKC-IN-1 是一种有效的 PKC beta II 抑制剂，Ki 为 14.9 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1796 | 有现货 |
|
| 5MG | ￥2746 | 有现货 |
|
| 25MG | ￥8872 | 有现货 |
|
| 50MG | ￥11532 | 有现货 |
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| 100MG | ￥15660 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥3021 | 有现货 |
|
生物学信息
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产品名称PKC beta II inhibitor H6
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PKC-IN-1 是一种有效的 PKC beta II 抑制剂，Ki 为 14.9 nM。
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产品描述PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM, extracted from patent WO 2008096260 A1 as compound example H6.
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体外实验PKC-IN-1 (Compound A) is a potent, ATP-competitive and reversible of conventional PKC enzymes with Kis of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.
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体内实验PKC-IN-1 (Compound A; 15 and 30 mg/kg, p.o., bid (twice a day)) dose-dependently and significantly reduces maximum EAE severity and end severity in autoimmune encephalitis (EAE) model in Lewis rats.
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同义词——
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通路Angiogenesis
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靶点PKC
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受体PKC
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研究领域Cancer
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适应症——
化学信息
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CAS Number1046787-18-1
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分子量500.623
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分子式C25H37FN8O2
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 25 mg/mL 49.94 mM
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SMILESCC1CN(C(CN1C(=O)N2CC3=C(C2(C)C)NN=C3NC4=NC(=NC=C4F)C)C)CC5CCOCC5
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化学全称((2S,5R)-2,5-dimethyl-4-((tetrahydro-2H-pyran-4-yl)methyl)piperazin-1-yl)(3-((5-fluoro-2-methylpyrimidin-4-yl)amino)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)methanone
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. 3-Aminopyrrolo[3,4-c]pyrazole-5(1H,4H,6H)carboxaldehyde derivatives as PKC inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. From PCT Int. Appl. (2008), WO 2008096260 A1 20080814.
产品手册
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