E1231 ( E-1231 )

产品货号. M10151 CAS No. 1031195-19-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

E1231
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

E1231 (E-1231) 是一种小分子 SIRT1 激活剂，EC50 为 0.83 uM。
产品描述

E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα); increases ATP-binding cassette transporter A1 (ABCA1) expression in RAW 264.7?cells dependent on SIRT1 and LXRα, promotes cholesterol efflux and inhibited lipid accumulation in RAW 264.7?cells via SIRT1 and ABCA1; decreases total cholesterol and triglyceride levels in both serum and the liver in golden hamster hyperlipidemia models.
体外实验

——
体内实验

Animal Model:HFD-diet Golden hamsters (80-90 g)Dosage:40 mg/kg Administration:PO; once daily for 7 days Result:Increased SIRT1 protein expression but not SIRT3, SIRT6, or SIRT7. And reduced liver and serum cholesterol in hamsters.Animal Model:Atherogenic diet ApoE-/- miceDosage:25, 50, and 100 mg/kg Administration:PO; once daily for 12 weeks Result:Modulated plaque composition, immunofluorescence staining. And reduced CD68 positive areas while increasing ABCA1 expression in the aortic sinus.
同义词

E-1231
通路

Chromatin/Epigenetic
靶点

Sirtuin
受体

Sirtuin
研究领域

——
适应症

——

CAS Number

1031195-19-3
分子量

363.417
分子式

C21H21N3O3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 100 mg/mL (275.17 mM)
SMILES

CC(N1CCN(C(C2=CC(C3=CC=C(C)O3)=NC4=CC=CC=C24)=O)CC1)=O
化学全称

1-(4-(2-(5-methylfuran-2-yl)quinoline-4-carbonyl)piperazin-1-yl)ethan-1-one

1. Feng T, et al. Atherosclerosis. 2018 Jul;274:172-181.

计算器

产品手册

关联产品

WAY-323061

WAY-323061 is a SIRT2 inhibitor.
Ophiopogonin D (b)

麦冬皂苷 D' 可以以剂量依赖性方式激活 SIRT1。 Ophiopogonin D' 还非竞争性抑制 UGT1A6 和 UGT1A10。
SIRT6-IN-5

SIRT6-IN-2 (Compound 5) 是一种选择性的 SIRT6 抑制剂 (IC50: 34 μM)。SIRT6-IN-2 增加 H3K9 的乙酰化并增加培养细胞中的葡萄糖摄取。SIRT6-IN-2 还可以减少 T 细胞增殖。SIRT6-IN-2 具有免疫抑制和化疗增敏作用。