LY2452473 ( TT 701 | OPK 88004 )

产品货号. M10141 CAS No. 1029692-15-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

LY2452473
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

LY2452473 (TT 701;OPK 88004) 是一种口服生物可利用的选择性雄激素受体调节剂 (SARM)，正在开发用于治疗与性腺功能减退症相关的疾病。
产品描述

LY2452473 (TT 701;OPK 88004) is an orally bioavailable selective androgen receptor modulator (SARM) being developed for the treatment of disorders related to hypogonadism; has the potential advantage of eliciting androgen receptor specificity and tissue selectivity to produce the beneficial effects of testosterone on bone, muscle, and improvements in erectile function over a PDE5i alone, with minimal steroid-related adverse effects.Prostate Cancer Phase 2 Clinical.
体外实验

——
体内实验

LY2452473 is a selective androgen receptor modulator being developed for the treatment of disorders related to hypogonadism. LY2452473 is absorbed rapidly (time to reach maximum plasma concentration for both LY2452473 and total radioactivity is 2-3 h) and cleared slowly (plasma terminal t1/2 of 27 h for LY2452473 and 51 h for the total radioactivity).
同义词

TT 701 | OPK 88004
通路

Endocrinology/Hormones
靶点

Androgen Receptor (AR)
受体

Androgen Receptor (AR)
研究领域

Cancer
适应症

Prostate Cancer

CAS Number

1029692-15-6
分子量

374.444
分子式

C22H22N4O2
纯度

>98% (HPLC)
溶解度

DMSO : 62.5 mg/mL 166.92 mM
SMILES

O=C(OC(C)C)N[C@H](C1)CC2=C1N(CC3=NC=CC=C3)C4=C2C=C(C#N)C=C4
化学全称

Isopropyl N-[(2S)-7-cyano-4-(2-pyridylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate

1. Yi P, et al. Drug Metab Dispos. 2012 Dec;40(12):2354-64. 2. Noey EL, et al. J Org Chem. 2017 Jun 2;82(11):5904-5909.

计算器

产品手册

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