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M1002
CAS No. 823830-85-9
M1002 ( —— )
产品货号. M35596 CAS No. 823830-85-9
M1002 是一种缺氧诱导因子-2 (HIF-2) 激动剂，可以增强 HIF-2 靶基因的表达。M1002 与脯氨酰羟化酶结构域 (PHD) 抑制剂可发挥协同作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥568 | 有现货 |
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| 5MG | ￥791 | 有现货 |
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| 10MG | ￥1252 | 有现货 |
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| 25MG | ￥2049 | 有现货 |
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| 50MG | ￥3042 | 有现货 |
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| 100MG | ￥4383 | 有现货 |
|
| 500MG | ￥9104 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称M1002
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述M1002 是一种缺氧诱导因子-2 (HIF-2) 激动剂，可以增强 HIF-2 靶基因的表达。M1002 与脯氨酰羟化酶结构域 (PHD) 抑制剂可发挥协同作用。
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产品描述M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors.
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体外实验M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy.M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors.RT-PCR Cell Line:786-O cells Concentration:10 μM Incubation Time:24 hoursResult:Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control.RT-PCR Cell Line:Hep3B cells Concentration:5 μM Incubation Time:24 hours Result:Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment.
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体内实验——
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同义词——
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通路Angiogenesis
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靶点HIF/HIF Prolyl-hydroxylase
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受体HIF
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研究领域——
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适应症——
化学信息
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CAS Number823830-85-9
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分子量394.29
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分子式C15H8F6N2O2S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (126.81 mM; 超声助溶 (<60°C); DMF 中的溶解度 : 50 mg/mL (126.81 mM; 超声助溶)
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SMILESFC(F)(F)C1=CC(=CC(NC2=NS(=O)(=O)C3=CC=CC=C23)=C1)C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Dalei Wu, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15(4):367-376.?
