FT-011

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种新型抗纤维化剂，可防止培养的肾系膜细胞中 TGF-β 刺激的胶原蛋白产生（30 uM 时抑制 55-70%）。

A novel anti-fibrotic agent that prevents TGF-beta-stimulated production of collagen in cultured renal mesangial cells (55-70% inhibition at 30 uM); inhibits both TGF-β1 and PDGF-BB induced collagen production as well as PDGF-BB-mediated mesangial proliferation, attenuates the decline in GFR, proteinuria and glomerulosclerosis in a robust model of non-diabetic kidney disease; attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy.(In Vivo):FT011 (100 mg/kg b.i.d., p.o., for 4 weeks) improves the cardiac function and and myocardial remodeling in myocardial infarction rats.

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FT011 (100 mg/kg b.i.d., p.o., for 4 weeks) improves the cardiac function and and myocardial remodeling in myocardial infarction rats. Animal Model:Seventy male Sprague Dawley (SD) rats (weighing 200-250 g)Dosage:100 mg/kg Administration:B.I.D., p.o. on day 7 after surgery, for 4 weeks Result:Increased ejection fraction, fraction shortening and preload recruitable stroke work.

FT011 | SHP-627

TGF-beta/Smad

TGFBR

TGFBR

Other Indications

Other Disease

1001288-58-9

351.3527

C20H17NO5

>98% (HPLC)

DMSO: ≥ 29 mg/mL

O=C(O)C1=CC=CC=C1NC(/C=C/C2=CC=C(OCC#C)C(OC)=C2)=O

Benzoic acid, 2-[[(2E)-3-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]-1-oxo-2-propen-1-yl]amino]-

(-20℃)

With Ice Pack

≥ 2 years