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M-525
CAS No. 2173582-08-4
M-525 ( M525 )
产品货号. M13475 CAS No. 2173582-08-4
M-525 是一种首创、高效、不可逆的 menin-MLL 相互作用小分子抑制剂，在 FP 测定中结合 IC50 为 3.3 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥12717 | 有现货 |
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| 50MG | ￥25758 | 有现货 |
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| 100MG | ￥34830 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称M-525
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述M-525 是一种首创、高效、不可逆的 menin-MLL 相互作用小分子抑制剂，在 FP 测定中结合 IC50 为 3.3 nM。
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产品描述M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays; inhibits MV4;11 (MLL fusion) and HL60 (No MLL fusion) cell growth with IC50 of 2.7 and 2,000 nM, respectively; significantly down-regulates the expression of MEIS1, HOXA9 and HOXA11 genes in a dosedependent anner at ow nanomolar concentrations, also effectively suppresses the expression of MEIS1 and HOX genes in the MOLM-13 cell line at 3 nM.
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体外实验M-525 achieves an IC50 of 3 nM in the MV4;11 cell line and has an IC50 of 2 μM in the HL-60 cell line. M-525 (3-300 nM; 24 h) is potent and effective in suppressing the expression of MEIS1 and HOX genes in MV4;11 cells carrying the MLL-AF4 fusion and in MOLM-13 cells carrying the MLL-AF9 fusion. It demonstrates high cellular specificity over non-MLL leukemia cells.
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体内实验——
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同义词M525
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通路Chromatin/Epigenetic
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靶点HMTase
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受体HMTase
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研究领域——
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适应症——
化学信息
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CAS Number2173582-08-4
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分子量734.932
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分子式C39H51FN6O5S
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(OC)N[C@@H]1[C@@H]([C@](C2=CC=CC(F)=C2)(C3CCN(CC4CN(C5=CC=C(S(=O)(C6CN(C(/C=C/CN(C)C)=O)C6)=O)C=C5)C4)CC3)O)CCC1
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化学全称methyl ((1S,2R)-2-((S)-cyano(1-((1-(4-((1-((E)-4-(dimethylamino)but-2-enoyl)azetidin-3-yl)sulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)(3-fluorophenyl)methyl)cyclopentyl)carbamate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Xu S, et al. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605.
