M-31850

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

M-31850 是一种有效、选择性和竞争性 β-己糖胺酶 (Hex) 抑制剂（人 HexA 和人 HexB，IC50 分别为 6.0 μM 和 3.1 μM）。

M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor(human HexA and human HexB with IC50s of 6.0 μM and 3.1 μM, respectively). IT also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM.(In Vitro):M-31850 shows some activity towards Jack Bean Hex (JBHex) and bacterial Hex from Streptomyces plicatus (SpHex) (IC50 of 280 μM and >500 μM for JBHex and SpHex, respectively).M-31850 produces a dose dependent increase in MUG hydrolysis (Hex S levels) in lysates from treated infantile Sandhoff disease (ISD) cells.M-31850 increases the half-life of the mutant Hex A from Adult forms of Tay-Sachs (ATSD) cells more than two-fold at 44° C, relative to the enzyme heated in the presence of DMSO. M-31850 acts as a classic competitive inhibitor of Hex (Km increases and Vmax is unaffected by increasing amounts of M-31850), with a Ki of 0.8 μM.

——

——

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-

Others

Other Targets

β-hexosaminidase (Hex)

——

——

281224-40-6

463.48

C28H21N3O4

>98% (HPLC)

DMSO:5 mg/mL?(10.79 mM;?ultrasonic and adjust pH to 6 with HCl)

C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCNCCN4C(=O)C5=CC=CC6=C5C(=CC=C6)C4=O

——

(-20℃)

With Ice Pack

≥ 2 years