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Luzindole

CAS No. 117946-91-5

Luzindole ( N-0774 )

产品货号. M23346 CAS No. 117946-91-5

Luzindole 是一种选择性褪黑激素受体拮抗剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1191 有现货
10MG ¥2017 有现货
25MG ¥3394 有现货
50MG ¥5006 有现货
100MG ¥7088 有现货
500MG ¥14175 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Luzindole
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Luzindole 是一种选择性褪黑激素受体拮抗剂。
  • 产品描述
    Luzindole is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1 (Mel1a) with Ki values of 10.2 and 158 nM for human MT2 and MT1, respectively.
  • 体外实验
    Luzindole (N-0774) (5-10 μg/ml) inhibits antigen-specific proliferation of the MBP-reactive LV-4 T cell line.
  • 体内实验
    Luzindole (N-0774) (30 mg/kg; i.p.; days 0-5) suppresses experimental autoimmune encephalomyelitis.Luzindole (N-0774) (30 mg/kg i.p.) reduces the time of immobility in a dose-dependent manner, the effect being more pronounced at midnight (60% reduction) than at noon (39% reduction). The effect of luzindole is time-dependent, showing a maximal effect at 60 min. The anti-immobility effect of luzindole (10 mg/kg i.p.) is prevented by the administration of melatonin (30 mg/kg i.p.). Luzindole (30 mg/kg i.p.) did not modify the time of immobility either at noon or midnight in the albino ND/4 mouse, or in the C57BL/6J mouse, which does not produce melatonin. Animal Model:Twenty-three- to 12-week-old(SJL X PL/J ) F1 mice Dosage:30 mg/kg Administration:i.p.; days 0-5 (between 23: 00 and 1: 00 under conditions of minimal lighting)Result:Effectively prevented experimental autoimmune encephalomyelitis.
  • 同义词
    N-0774
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    MT1 receptor|MT2 receptor
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    117946-91-5
  • 分子量
    292.37
  • 分子式
    C19H20N2O
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:100 mg/mL (342.03 mM; Need ultrasonic)
  • SMILES
    CC(NCCc1c(Cc2ccccc2)[nH]c2c1cccc2)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Dubocovich ML, et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):365-75.
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