Loxiglumide ( CR-1505; Loxiglumide, brand name: Loxizin. )

产品货号. M17793 CAS No. 107097-80-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Loxiglumide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist.
产品描述

Loxiglumide is a potent, orally active, and selective CCK-A receptor antagonist which stimulates calorie intake and hunger feelings in humans. Loxiglumide inhibits pancreatic secretion of digestive enzymes, and also blocks CCK-induced gastric secretions and emptying. Intravenous administration of loxiglumide antagonized the CCK-induced reduction of gastric emptying in rats, acceleration of intestinal transport in mice, increase in ileal motility in rabbits, gallbladder contraction in guinea pigs and acceleration of gallbladder emptying in mice.
同义词

CR-1505; Loxiglumide, brand name: Loxizin.
通路

Others
靶点

Other Targets
受体

CCK
研究领域

——
适应症

——

CAS Number

107097-80-3
分子量

461.38
分子式

C21H30Cl2N2O5
纯度

98%
溶解度

DMSO : ≥ 150 mg/mL; 325.11 mM
SMILES

CCCCCN(CCCOC)C(=O)C(CCC(=O)O)NC(=O)c1cc(c(cc1)Cl)Cl
化学全称

4-(3,4-dichlorobenzamido)-5-((3-methoxypropyl)(pentyl)amino)-5-oxopentanoic acid

1. Teyssen S, et al. Pancreas. 1996 Nov;13(4):407-16.2. Shiratori K, et al. Pancreas. 2002 Jul;25(1):e1-5.

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