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Loxiglumide

CAS No. 107097-80-3

Loxiglumide ( CR-1505 | Loxiglumide, brand name: Loxizin. )

产品货号. M17793 CAS No. 107097-80-3

Loxiglumide 是一种胆囊收缩素 (CCK-1) 受体拮抗剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥275 有现货
10MG ¥462 有现货
25MG ¥964 有现货
50MG ¥1920 有现货
100MG ¥3378 有现货
500MG ¥7679 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Loxiglumide
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Loxiglumide 是一种胆囊收缩素 (CCK-1) 受体拮抗剂。
  • 产品描述
    Loxiglumide is a potent, orally active, and selective CCK-A receptor antagonist which stimulates calorie intake and hunger feelings in humans. Loxiglumide inhibits pancreatic secretion of digestive enzymes, and also blocks CCK-induced gastric secretions and emptying. Intravenous administration of loxiglumide antagonized the CCK-induced reduction of gastric emptying in rats, acceleration of intestinal transport in mice, increase in ileal motility in rabbits, gallbladder contraction in guinea pigs and acceleration of gallbladder emptying in mice.
  • 体外实验
    ——
  • 体内实验
    The effects of pancreatic rest by oral administration of CCK-1 receptor antagonist Loxiglumide and pancreas stimulation are investigated via endogenous CCK release induced by po protease inhibitor camostat on the recovery of pancreatic secretory function, and biochemical and histological changes of the pancreas after acute hemorrhagic pancreatitis. Oral administration of CCK-1 receptor antagonist Loxiglumide with a dose of 50 mg/kg body weight inhibits pancreatic exocrine secretion for more than 12 h. Thus, every 12-h administration of Loxiglumide might have completely blocks the effect of endogenously released CCK on the pancreas (pancreatic rest).
  • 同义词
    CR-1505 | Loxiglumide, brand name: Loxizin.
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    CCK
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    107097-80-3
  • 分子量
    461.38
  • 分子式
    C21H30Cl2N2O5
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 150 mg/mL; 325.11 mM
  • SMILES
    CCCCCN(CCCOC)C(=O)C(CCC(=O)O)NC(=O)c1cc(c(cc1)Cl)Cl
  • 化学全称
    4-(3,4-dichlorobenzamido)-5-((3-methoxypropyl)(pentyl)amino)-5-oxopentanoic acid

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Teyssen S, et al. Pancreas. 1996 Nov;13(4):407-16.2. Shiratori K, et al. Pancreas. 2002 Jul;25(1):e1-5.
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