
Lonidamine
CAS No. 50264-69-2
Lonidamine ( AF 1890 | DICA | Diclondazolic Acid )
产品货号. M14699 CAS No. 50264-69-2
Lonidamine 是一种口服小分子己糖激酶灭活剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥267 | 有现货 |
![]() ![]() |
5MG | ¥365 | 有现货 |
![]() ![]() |
10MG | ¥470 | 有现货 |
![]() ![]() |
25MG | ¥608 | 有现货 |
![]() ![]() |
50MG | ¥948 | 有现货 |
![]() ![]() |
100MG | ¥1231 | 有现货 |
![]() ![]() |
500MG | ¥3021 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Lonidamine
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Lonidamine 是一种口服小分子己糖激酶灭活剂。
-
产品描述Lonidamine is an orally administered small molecule hexokinase inactivator.(In Vitro):Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.(In Vivo):Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.
-
体外实验Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.
-
体内实验Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model. Animal Model:Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.Dosage:10, 30, 100 mg/kg/day Administration:Oral administration, daily, d10 to d20 after BLM treatment.Result:Partially or completely reversed the increases in HK2 and lactate induced by BLM and reduced the expression of 10 profibrotic mediators.
-
同义词AF 1890 | DICA | Diclondazolic Acid
-
通路Others
-
靶点Other Targets
-
受体hexokinase
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number50264-69-2
-
分子量321.17
-
分子式C15H10Cl2N2O2
-
纯度>98% (HPLC)
-
溶解度DMSO: 64 mg/mL (199.27 mM)
-
SMILESO=C(C1=NN(CC2=CC=C(Cl)C=C2Cl)C3=C1C=CC=C3)O
-
化学全称1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Floridi A, et al. J Natl Y Inst, 1981, 66(3), 497-499.
产品手册




关联产品
-
19-O-beta-D-carboxyg...
19-O-beta-D-carboxyglucopyranosyl-12-O-beta-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene is a natural product of Pinus, Pinaceae.
-
NSC45586
NSC45586 是一种蛋白磷酸酶 PHLPP 抑制剂,对 PHLPP1 和 PHLPP2 具有选择性。
-
Tyroserleutide
酪丝亮肽 (YSL) 是从猪脾脏的降解产物中分离出来的,是一种小分子三肽,可在体外和体内抑制肿瘤生长。