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Lonidamine

CAS No. 50264-69-2

Lonidamine ( AF 1890 | DICA | Diclondazolic Acid )

产品货号. M14699 CAS No. 50264-69-2

Lonidamine 是一种口服小分子己糖激酶灭活剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥267 有现货
5MG ¥365 有现货
10MG ¥470 有现货
25MG ¥608 有现货
50MG ¥948 有现货
100MG ¥1231 有现货
500MG ¥3021 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Lonidamine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Lonidamine 是一种口服小分子己糖激酶灭活剂。
  • 产品描述
    Lonidamine is an orally administered small molecule hexokinase inactivator.(In Vitro):Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.(In Vivo):Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.
  • 体外实验
    Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.
  • 体内实验
    Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model. Animal Model:Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.Dosage:10, 30, 100 mg/kg/day Administration:Oral administration, daily, d10 to d20 after BLM treatment.Result:Partially or completely reversed the increases in HK2 and lactate induced by BLM and reduced the expression of 10 profibrotic mediators.
  • 同义词
    AF 1890 | DICA | Diclondazolic Acid
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    hexokinase
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    50264-69-2
  • 分子量
    321.17
  • 分子式
    C15H10Cl2N2O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 64 mg/mL (199.27 mM)
  • SMILES
    O=C(C1=NN(CC2=CC=C(Cl)C=C2Cl)C3=C1C=CC=C3)O
  • 化学全称
    1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Floridi A, et al. J Natl Y Inst, 1981, 66(3), 497-499.
产品手册
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