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Lomibuvir
CAS No. 1026785-55-6
Lomibuvir ( —— )
产品货号. M35911 CAS No. 1026785-55-6
Lomibuvir (VX-222) 是一种选择性的非核苷聚合酶抑制剂，靶向丙型肝炎病毒 NS5B 聚合酶 (RdRp) 的拇指口袋 2，Kd 为 17 nM。Lomibuvir 抑制 1b/Con1 型 HCV 亚基因组复制子，EC50 为 5.2 nM。Lomibuvir 优先抑制延长的 RNA 合成，而非从头合成的 RNA。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥530 | 有现货 |
|
| 5MG | ￥783 | 有现货 |
|
| 10MG | ￥1389 | 有现货 |
|
| 25MG | ￥2448 | 有现货 |
|
| 50MG | ￥4082 | 有现货 |
|
| 100MG | ￥6219 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Lomibuvir
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Lomibuvir (VX-222) 是一种选择性的非核苷聚合酶抑制剂，靶向丙型肝炎病毒 NS5B 聚合酶 (RdRp) 的拇指口袋 2，Kd 为 17 nM。Lomibuvir 抑制 1b/Con1 型 HCV 亚基因组复制子，EC50 为 5.2 nM。Lomibuvir 优先抑制延长的 RNA 合成，而非从头合成的 RNA。
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产品描述Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis.
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体外实验Lomibuvir (VX-222) inhibits WT HCV 1b/Con1 replicon with an EC50 of 5.2 nM. Lomibuvir inhibits M423T, L419M and I482L (mutant replicons) with EC50s of 79.8, 563.1, 45.3 nM, respectively. Lomibuvir reduces de novo initiation slightly but also shows strong inhibition of primer extension. The IC50 of Lomibuvir for primer-extended RNA synthesis is 31 nM.Lomibuvir is a non-nucleoside, allosteric inhibitor of the hepatitis C virus NS5B polymerase.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体HCV Protease
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研究领域——
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适应症——
化学信息
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CAS Number1026785-55-6
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分子量445.61
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分子式C25H35NO4S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (224.41 mM; 超声助溶 )
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SMILESCC1CCC(CC1)C(=O)N(C1CCC(O)CC1)c1cc(sc1C(O)=O)C#CC(C)(C)C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yi G, Deval J, et al. Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir. Antimicrob Agents Chemother. 2012;56(2):830-837.?
产品手册
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