Lodoxamide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Lodoxamide is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.

Lodoxamide is a potent agonist of GPR35 with an EC50 value of 1.61 nM in a β-arrestin-2 interaction assay using CHO-K1 cells expressing the human receptor. It inhibits histamine release induced by compound 48/80 (Item No. 22173), anti-IgE, or A23187 (Item No. 11016) in isolated rat peritoneal mast cells (IC50s = 0.1-50 μM) and inhibits A23187-induced calcium influx in mast cells. It reduces antigen-induced histamine release from rat conjunctival tissue by 46% in vitro when used at a concentration of 10 μg/ml. Lodoxamine (0.1 and 10%, w/v) reduces the immediate hypersensitivity response in rat conjunctiva in vivo in a dose-dependent manner and reduces mast cell degranulation in a topical ovalbumin challenge. Formulations containing lodoxamide have been used in the treatment of vernal conjunctivitis and keratitis.

Lodoxamide; Lodoxamidum; Lodoxamida

Others

Other Targets

Histamine Receptor

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53882-12-5

311.63

C11H6ClN3O6

98%

DMSO : ≥ 30 mg/mL; 96.27 mM

OC(=O)C(=O)Nc1cc(cc(NC(=O)C(O)=O)c1Cl)C#N

2,2'-((2-chloro-5-cyano-1,3-phenylene)bis(azanediyl))bis(2-oxoacetic acid)

(-20℃)

With Ice Pack

≥ 2 years