Lidamidine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

利达脒是一种有效的止泻药，可抑制肠道分泌，减少肠道运输，并抑制平滑肌收缩。

Lidamidine is an effective antidiarrheal agent that inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction.(In Vivo):Fasted male rats were anesthetised and equipped with an intraluminal cannula positioned at the proximal end of a 10 cm fluid-filled segment of the ascending colon (basal pressure, 10 cm H2O). Intraluminal pressure was monitored by a transducer attached to a closed fluid-filled system. All drugs were administered intravenously by slow infusion. A regular pattern of distinct contractile complexes was observed over a 70 min period. These contractions increased intraluminal pressure to 39 +/- 1.2 cm H2O (mean +/- S.E.), occurred at a frequency of 0.3 per min and lasted from 1 to 2.5 min. Inhibition of these contractile patterns was observed with either atropine (0.1 mg/kg) or lidamidine (3.0 mg/kg). A 20 min pretreatment with idazoxan (3.0 mg/kg) antagonized lidamidine's but not atropine's effect. Trimazosin (1 mg/kg) or propranolol (0.3 mg/kg) pretreatment did not antagonize the lidamidine-generated inhibition.

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Lidamidina | Lidamidinum

Others

Other Targets

H1 receptor

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66871-56-5

220.276

C11H16N4O

>98% (HPLC)

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CNC(=N)NC(=O)Nc1c(C)cccc1C

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(-20℃)

With Ice Pack

≥ 2 years