
Licoricidin
CAS No. 30508-27-1
Licoricidin ( —— )
产品货号. M31497 CAS No. 30508-27-1
Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥4906 | 有现货 |
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50MG | 获取报价 | 有现货 |
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100MG | 获取报价 | 有现货 |
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生物学信息
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产品名称Licoricidin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
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产品描述Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
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体外实验Licoricidin (LCD) (0-20 μM; 24 hours) dose-dependently inhibits the viability of colon cancer cell lines with various pathological and genetic characters, namely SW480, HCT116, SW620 and LoVo cells, with IC50 values of 7.2, 5.4, 4.5 and 5.1 μM, respectively.Licoricidin (LCD) (0-20 μM; 0-12 hours) induces cell apoptosis was accompanied with the activation of caspase-3 by cleavage in a time- and dose-dependent manner.Licoricidin (LCD) (0-20 μM; 0-12 hours) induces autophagy of SW480 cells, increases the cleavage of LC3-I to LC3-II and the degradation of p62 in a time and dose dependent manner.Licoricidin (LCD) (0-5 μg/ml; 18 hours) inhibits cell migration, MMP-9 secretion, and VCAM expression in 4T1 cells.Cell Viability Assay Cell Line:SW480, HCT116, SW620 and LoVo cells Concentration:0-20 μM Incubation Time:24 hours Result:Decreased colon cancer cell lines viability.Western Blot Analysis Cell Line:SW480 cells Concentration:0 μM, 2.5 μM, 5 μM, 10 μM, 20 μM Incubation Time:0 hours, 1 hour, 3 hours, 6 hours, 12 hours Result:Induced cell apoptosis.
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体内实验Licoricidin (LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 15 days) significantly inhibited the growth of SW480 xenografts in nude mice with an inhibitory rate of 43.5%.Licoricidin (LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days) reduces pulmonary metastasis and the expression of CD45, CD31, HIF-1α, iNOS, COX-2, and VEGF-A in tumor tissues, additionally, decreases protein expression of VEGF-R2, VEGF-C, VEGF-R3, and LYVE-1 in tumor tissues of licoricidin-treated mice. Animal Model:SW480 xenografted tumor growth in nude mice Dosage: 5, 10, or 20 mg/kg Administration:Intraperitoneal injection; once daily; 15 days Result:Decreased tumor volumes.Animal Model:BALB/c mouse orthotopic model Dosage:5, 10, or 20 mg/kg Administration:Intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days Result:Inhibited Lung Metastasis of 4T1 Murine Mammary Carcinoma cells.
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number30508-27-1
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分子量424.5
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分子式C26H32O5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (235.55 mM)
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SMILES——
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册




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