
Licarbazepine
CAS No. 29331-92-8
Licarbazepine ( Licarbazepine | ?1011-hydroxy-1011 Dihydrocarbamezer )
产品货号. M21077 CAS No. 29331-92-8
利卡西平是奥卡西平的药理活性代谢物,奥卡西平是一种用于治疗部分性癫痫发作和双相情感障碍的化合物。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
50MG | ¥786 | 有现货 |
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100MG | ¥988 | 有现货 |
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200MG | ¥1442 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Licarbazepine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述利卡西平是奥卡西平的药理活性代谢物,奥卡西平是一种用于治疗部分性癫痫发作和双相情感障碍的化合物。
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产品描述Licarbazepine is the pharmacologically active metabolite of oxcarbazepine a drug indicated for the treatment of partial seizures and bipolar disorders.(In Vivo):Eslicarbazepine acetate (ESL) is an oral pro-drug that is rapidly and extensively metabolized by the liver via a hydrolytic first-pass metabolism into S-Licarbazepine, the biologically active drug. The plasma level of the prodrug remains below quantification.ESL is a potent antiepileptic agent with a spectrum of action essentially limited to partial-onset and generalized tonic-clonic seizures. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL works by blocking the voltage-gated sodium channel, which play an essential role in the generation and propagation of the epileptic discharge. ESL is well absorbed after oral administration with a bio-availability about 16% higher than that observed after an equivalent dose of Oxcarbazepine (OXC).
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体外实验——
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体内实验Eslicarbazepine acetate (ESL) is an oral pro-drug that is rapidly and extensively metabolized by the liver via a hydrolytic first-pass metabolism into S-Licarbazepine, the biologically active drug. The plasma level of the prodrug remains below quantification. ESL is a potent antiepileptic agent with a spectrum of action essentially limited to partial-onset and generalized tonic-clonic seizures. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL works by blocking the voltage-gated sodium channel, which play an essential role in the generation and propagation of the epileptic discharge.?ESL is well absorbed after oral administration with a bio-availability about 16% higher than that observed after an equivalent dose of Oxcarbazepine (OXC).
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同义词Licarbazepine | ?1011-hydroxy-1011 Dihydrocarbamezer
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通路Others
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靶点Other Targets
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受体Others
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研究领域Neurological Disease
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适应症Bipolar Disorder
化学信息
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CAS Number29331-92-8
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分子量254.28
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分子式C15H14N2O2
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纯度>98% (HPLC)
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溶解度DMSO:3mg/ml(11.7mM)
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SMILESNC(=O)N1c2ccccc2CC(O)c2ccccc21
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化学全称10-hydroxy-1011-dihydro-5H-dibenzo[bf]azepine-5-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Begas E Tsakalof A Dardiotis E et al. Development and validation of a reversed-phase HPLC method for licarbazepine monitoring in serum of patients under oxcarbazepine treatment: HPLC method for licarbazepine monitoring in serum of patients[J]. Biomedical Chromatography 2017 31(9).
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