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Licarbazepine

CAS No. 29331-92-8

Licarbazepine ( Licarbazepine | ?1011-hydroxy-1011 Dihydrocarbamezer )

产品货号. M21077 CAS No. 29331-92-8

利卡西平是奥卡西平的药理活性代谢物,奥卡西平是一种用于治疗部分性癫痫发作和双相情感障碍的化合物。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
50MG ¥786 有现货
100MG ¥988 有现货
200MG ¥1442 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Licarbazepine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    利卡西平是奥卡西平的药理活性代谢物,奥卡西平是一种用于治疗部分性癫痫发作和双相情感障碍的化合物。
  • 产品描述
    Licarbazepine is the pharmacologically active metabolite of oxcarbazepine a drug indicated for the treatment of partial seizures and bipolar disorders.(In Vivo):Eslicarbazepine acetate (ESL) is an oral pro-drug that is rapidly and extensively metabolized by the liver via a hydrolytic first-pass metabolism into S-Licarbazepine, the biologically active drug. The plasma level of the prodrug remains below quantification.ESL is a potent antiepileptic agent with a spectrum of action essentially limited to partial-onset and generalized tonic-clonic seizures. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL works by blocking the voltage-gated sodium channel, which play an essential role in the generation and propagation of the epileptic discharge. ESL is well absorbed after oral administration with a bio-availability about 16% higher than that observed after an equivalent dose of Oxcarbazepine (OXC).
  • 体外实验
    ——
  • 体内实验
    Eslicarbazepine acetate (ESL) is an oral pro-drug that is rapidly and extensively metabolized by the liver via a hydrolytic first-pass metabolism into S-Licarbazepine, the biologically active drug. The plasma level of the prodrug remains below quantification. ESL is a potent antiepileptic agent with a spectrum of action essentially limited to partial-onset and generalized tonic-clonic seizures. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL works by blocking the voltage-gated sodium channel, which play an essential role in the generation and propagation of the epileptic discharge.?ESL is well absorbed after oral administration with a bio-availability about 16% higher than that observed after an equivalent dose of Oxcarbazepine (OXC).
  • 同义词
    Licarbazepine | ?1011-hydroxy-1011 Dihydrocarbamezer
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Neurological Disease
  • 适应症
    Bipolar Disorder

化学信息

  • CAS Number
    29331-92-8
  • 分子量
    254.28
  • 分子式
    C15H14N2O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:3mg/ml(11.7mM)
  • SMILES
    NC(=O)N1c2ccccc2CC(O)c2ccccc21
  • 化学全称
    10-hydroxy-1011-dihydro-5H-dibenzo[bf]azepine-5-carboxamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Begas E Tsakalof A Dardiotis E et al. Development and validation of a reversed-phase HPLC method for licarbazepine monitoring in serum of patients under oxcarbazepine treatment: HPLC method for licarbazepine monitoring in serum of patients[J]. Biomedical Chromatography 2017 31(9).
产品手册
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