Leteprinim

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Leteprinim 是一种次黄嘌呤衍生物，可刺激体外神经突生长以及星形胶质细胞产生腺苷和神经营养素。

Leteprinim is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes.(In Vitro):Leteprinim stimulates the outgrowth of neurites from PC12 cells and neurons, stimulates the synthesis and/or release of neurotrophic factors from astrocytes, enhances nerve fibre regeneration in vivo, and enhances memory in animals and humans. Leteprinim also protects against glutamate neurotoxicity in vitro and in vivo, which has led to successful tests of Leteprinim in animal models of acute central nervous system injury.(In Vivo):Leteprinim (60 mg/kg/day; i.p., for 7 days, starting from 20 min before the kainate injection) did not modify the seizures caused by kainate but, like diazepam, it decreased kainate-induced mortality, the reduction of GAD activity, and the loss of hippocampal neurons in rats.

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AIT 082 acid | AIT-082 acid | AIT082 acid

Others

Other Targets

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138117-50-7

327.3

C15H13N5O4

>98% (HPLC)

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OC(=O)c1ccc(NC(=O)CCn2cnc3c2nc[nH]c3=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years