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Lauroseptol

CAS No. 57-09-0

Lauroseptol ( Cetrimonium bromide | NSC 32927 | NSC-32927 | NSC32927 )

产品货号. M15078 CAS No. 57-09-0

西曲溴铵是广谱抗菌剂西曲溴铵的已知成分,它是不同季铵盐的混合物。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
100MG ¥316 有现货
200MG ¥446 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Lauroseptol
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    西曲溴铵是广谱抗菌剂西曲溴铵的已知成分,它是不同季铵盐的混合物。
  • 产品描述
    Cetrimonium Bromide is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts.
  • 体外实验
    Cetrimonium bromide (1-5 μM, 24 h) cannot affect growth of SK-HEP-1 cells.Cetrimonium bromide (5 μM, 16-24 h) attenuates cellular migration and invasion of SK-HEP-1cells.Cetrimonium bromide (5 μM, 24 h) inhibits the protein expression of MMP-2 and MMP-9, increases the protein expression of TIMP-1 and TIMP-2 and restrain the protein expression of Rac1, cdc42 and RhoA in SK-HEP-1cells.Cetrimonium bromide (5 μM, 12-72 h) induces apoptosis in human Head and neck cancer (HNC) cells.Cell Viability Assay Cell Line:SK-HEP-1 cells Concentration:1 μM, 2.5 μM, 5 μM Incubation Time:24 h Result:Retained more than 90% cell viability at 24 hours.Cell Cycle Analysis Cell Line:HNC cells Concentration:5 μM Incubation Time:12 h, 24 h, 48 h, 72 h Result:Induced caspase activation.Observed the activation of the caspase cascade and increased in a time-dependent manner.Western Blot Analysis Cell Line:SK-HEP-1 cells Concentration:1 μM, 2.5 μM, 5 μM Incubation Time:24 h Result:Significantly down-regulates MMP-2 and MMP-9 expressions in SK-HEP-1 cells in a dose-dependent manner.Significantly increased the protein expression of TIMP-1 and TIMP-2.Negatively affects the protein levels of Rac1, cdc42 and RhoA in SK-HEP-1 cells.
  • 体内实验
    Animal Model:FaDu cells tumor-bearing miceDosage:5 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Induced a modest reduction in tumor development.Delayed the mean time to reach a tumor-plus-leg diameters (TLD) of 14mm by ~3.7 days.Animal Model:Sprague-Dawley rats Dosage:10 mg/kg, 20 mg/kg, 45 mg/kg Administration:Supplemented in drinking water Result:Showed lower body weight at highest concentration within 3 weeks.Reduced the body weight throughout the experimental in males and skeletal growth at highest dose level in both males and females.Significantly decreased efficiency of food conversion in male rats receiving the highest dose.
  • 同义词
    Cetrimonium bromide | NSC 32927 | NSC-32927 | NSC32927
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    57-09-0
  • 分子量
    364.46
  • 分子式
    C19H42BrN
  • 纯度
    >98% (HPLC)
  • 溶解度
    Ethanol: 100 mg/mL (274.38 mM); Water: 100 mg/mL (274.38 mM); DMSO: 5 mg/mL (13.71 mM)
  • SMILES
    CCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-]
  • 化学全称
    1-Hexadecanaminium, N,N,N-trimethyl-, bromide (1:1)

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Ito E, et al. Mol Pharmacol, 2009, 76(5), 969-983.
产品手册
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