Lauroseptol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

西曲溴铵是广谱抗菌剂西曲溴铵的已知成分，它是不同季铵盐的混合物。

Cetrimonium Bromide is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts.

Cetrimonium bromide (1-5 μM, 24 h) cannot affect growth of SK-HEP-1 cells.Cetrimonium bromide (5 μM, 16-24 h) attenuates cellular migration and invasion of SK-HEP-1cells.Cetrimonium bromide (5 μM, 24 h) inhibits the protein expression of MMP-2 and MMP-9, increases the protein expression of TIMP-1 and TIMP-2 and restrain the protein expression of Rac1, cdc42 and RhoA in SK-HEP-1cells.Cetrimonium bromide (5 μM, 12-72 h) induces apoptosis in human Head and neck cancer (HNC) cells.Cell Viability Assay Cell Line:SK-HEP-1 cells Concentration:1 μM, 2.5 μM, 5 μM Incubation Time:24 h Result:Retained more than 90% cell viability at 24 hours.Cell Cycle Analysis Cell Line:HNC cells Concentration:5 μM Incubation Time:12 h, 24 h, 48 h, 72 h Result:Induced caspase activation.Observed the activation of the caspase cascade and increased in a time-dependent manner.Western Blot Analysis Cell Line:SK-HEP-1 cells Concentration:1 μM, 2.5 μM, 5 μM Incubation Time:24 h Result:Significantly down-regulates MMP-2 and MMP-9 expressions in SK-HEP-1 cells in a dose-dependent manner.Significantly increased the protein expression of TIMP-1 and TIMP-2.Negatively affects the protein levels of Rac1, cdc42 and RhoA in SK-HEP-1 cells.

Animal Model:FaDu cells tumor-bearing miceDosage:5 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Induced a modest reduction in tumor development.Delayed the mean time to reach a tumor-plus-leg diameters (TLD) of 14mm by ~3.7 days.Animal Model:Sprague-Dawley rats Dosage:10 mg/kg, 20 mg/kg, 45 mg/kg Administration:Supplemented in drinking water Result:Showed lower body weight at highest concentration within 3 weeks.Reduced the body weight throughout the experimental in males and skeletal growth at highest dose level in both males and females.Significantly decreased efficiency of food conversion in male rats receiving the highest dose.

Cetrimonium bromide | NSC 32927 | NSC-32927 | NSC32927

Others

Other Targets

Others

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57-09-0

364.46

C19H42BrN

>98% (HPLC)

Ethanol: 100 mg/mL (274.38 mM); Water: 100 mg/mL (274.38 mM); DMSO: 5 mg/mL (13.71 mM)

CCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-]

1-Hexadecanaminium, N,N,N-trimethyl-, bromide (1:1)

(-20℃)

With Ice Pack

≥ 2 years