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Lanperisone
CAS No. 116287-14-0
Lanperisone ( NK 433 )
产品货号. M10560 CAS No. 116287-14-0
Lanperisone (NK 433) 是一种中枢性肌肉松弛剂，能够以不依赖于细胞周期的方式选择性杀死 K-ras 突变癌细胞。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
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| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Lanperisone
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Lanperisone (NK 433) 是一种中枢性肌肉松弛剂，能够以不依赖于细胞周期的方式选择性杀死 K-ras 突变癌细胞。
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产品描述Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion; shows potent and selective activity against K-rasG12D MEFs with IC50 of 4 uM in the CTG viability assay; causes a large population of cells with sub-2N DNA content, induces oxidative stress, but not in wild-type MEFs; suppresses the growth of K-ras-driven tumors without overt toxicity in mice; orally bioactive.
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体外实验——
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体内实验——
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同义词NK 433
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通路MAPK/ERK Signaling
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靶点Ras
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受体Ras
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研究领域——
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适应症——
化学信息
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CAS Number116287-14-0
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分子量285.305
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分子式C15H18F3NO
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1=CC=C(C(F)(F)F)C=C1)[C@H](C)CN2CCCC2
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化学全称(2R)-2-methyl-3-pyrrolidin-1-yl-1-[4-(trifluoromethyl)phenyl]propan-1-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Shaw AT, et al. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8773-8.
2. Sakitama K, et al. Eur J Pharmacol. 1997 Oct 22;337(2-3):175-87.
3. Glasauer A, et al. Biochem Pharmacol. 2014 Nov 1;92(1):90-101.
