Lactisole

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Lactisole is an inhibitor of the glucose-sensing receptor.

Lactisole is an inhibitor of the glucose-sensing receptor.(In Vitro):In MIN6 cells, in a dose-dependent manner, lactisole inhibited insulin secretion induced by sweeteners, acesulfame-K, sucralose and glycyrrhizin. The IC50 was ～4 mmol/l. Lactisole attenuated the elevation of cytoplasmic Ca2+ concentration ([Ca2+]c) evoked by sucralose and acesulfame-K but did not affect the elevation of intracellular cAMP concentration ([cAMP]c) induced by these sweeteners. Lactisole also inhibited the action of glucose in MIN6 cells. Thus, lactisole significantly reduced elevations of intracellular [NADH] and intracellular [ATP] induced by glucose, and also inhibited glucose-induced insulin secretion.

2-(4-Methoxyphenoxy)propanoic acid

Others

Other Targets

Apoptosis;PKG

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150436-68-3

218.2

C10H11NaO4

>98% (HPLC)

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[Na+].COc1ccc(OC(C)C([O-])=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years