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LY377604
CAS No. 204592-94-9
LY377604 ( —— )
产品货号. M33416 CAS No. 204592-94-9
LY377604 是一种人类 β3-肾上腺素受体激动剂，其 EC50 值为 2.4 nM，同时也是 β1 和 β2 肾上腺素能受体的拮抗剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1641 | 有现货 |
|
| 5MG | ￥2568 | 有现货 |
|
| 10MG | ￥3811 | 有现货 |
|
| 25MG | ￥6045 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称LY377604
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述LY377604 是一种人类 β3-肾上腺素受体激动剂，其 EC50 值为 2.4 nM，同时也是 β1 和 β2 肾上腺素能受体的拮抗剂。
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产品描述LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist.
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体外实验LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist. LY377604 causes a maximal increase in cyclic adenosine monophosphate (cAMP) levels, but does not stimulate cAMP accumulation in CHO cells transfected with either the human β1 adrenergic receptor or the human β2 adrenergic receptor.
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体内实验Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats.
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同义词——
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通路GPCR/G Protein
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靶点Adrenergic Receptor
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受体Adrenergic Receptor
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研究领域——
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适应症——
化学信息
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CAS Number204592-94-9
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分子量524.61
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分子式C31H32N4O4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (190.62 mM; 超声助溶 )
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SMILESO(C[C@H](CNC(CC1=CC=C(OC2=CC=C(C(N)=O)C=N2)C=C1)(C)C)O)C3=C4C=5C(NC4=CC=C3)=CC=CC5
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Jesudason CD, et al. Combination of a Beta adrenoceptor modulator and a norepinephrine-serotonin uptake inhibitor for the treatment of obesity. ACS Med Chem Lett. 2011 May 23;2(8):583-6.?
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