LW6
CAS No. 934593-90-5
LW6 ( CAY10585; CAY-10585; CAY 10585; LW6 )
产品货号. M17673 CAS No. 934593-90-5
LW6 is a novel HIF-1 inhibitor.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥316 | 有现货 |
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5MG | ¥510 | 有现货 |
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10MG | ¥737 | 有现货 |
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25MG | ¥1563 | 有现货 |
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50MG | ¥2535 | 有现货 |
|
100MG | ¥3823 | 有现货 |
|
500MG | ¥7995 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称LW6
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述LW6 is a novel HIF-1 inhibitor.
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产品描述CAY10585, also known as LW6, was first identified and reported by a group scientists from Korea. LW8 was found to inhibits the accumulation of HIF-1alpha. LW6 decreased HIF-1alpha protein expression without affecting HIF-1beta expression. It was further found that LW8 promoted the degradation of wild type HIF-1alpha, but not of a DM-HIF-1alpha with modifications of P402A and P564A, at hydroxylation sites in the oxygen-dependent degradation domain (ODDD). LW6 did not affect the activity of prolyl hydroxylase (PHD), but induced the expression of von Hippel-Lindau (VHL), which interacts with prolyl-hydroxylated HIF-1alpha for proteasomal degradation. In the presence of LW8, knockdown of VHL did not abolish HIF-1alpha protein accumulation, indicating that LW8 degraded HIF-1alpha via regulation of VHL expression. In mice carrying xenografts of human colon cancer HCT116 cells, LW8 demonstrated strong anti-tumor efficacy in vivo and caused a decrease in HIF-1alpha expression in frozen-tissue immunohistochemical staining. These data suggest that LW8 may be valuable in the development of a HIF-1alpha inhibitor for cancer treatment.
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同义词CAY10585; CAY-10585; CAY 10585; LW6
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通路Others
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靶点Other Targets
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受体HIF-1
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研究领域Cancer
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适应症——
化学信息
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CAS Number934593-90-5
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分子量435.52
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分子式C26H29NO5
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纯度98%
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溶解度DMSO : ≥ 33 mg/mL; 75.77 mM
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SMILESO=C(OC)C1=CC=C(O)C(NC(COC2=CC=C(C3(C4)CC5CC4CC(C5)C3)C=C2)=O)=C1
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化学全称methyl 3-(2-(4-(adamantan-1-yl)phenoxy)acetamido)-4-hydroxybenzoate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Naik R, et al. J Med Chem. 2014 Nov 26;57(22):9522-38.
产品手册
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