LTURM34

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LTURM34 是一种 DNA-PK 抑制剂，IC50 为 34 nM。 LTURM34 在多种肿瘤细胞系中显示出有效的抗增殖活性。

LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line. LTURM34 displays effective inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms (IC50s: 5.8 and 8.5 μM for PI3K β and δ, respectively) .

LTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC50s are 5.8 and 8.5 μM for PI3K β and δ, respectively. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line.

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PI3K/Akt/mTOR signaling

PI3K

DNA-PK|PI3Kβ|PI4Kδ

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1879887-96-3

414.48

C24H18N2O3S

>98% (HPLC)

DMSO:60 mg/mL (144.76 mM)

O=c1nc(oc2c(cccc12)-c1cccc2c3ccccc3sc12)N1CCOCC1

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(-20℃)

With Ice Pack

≥ 2 years