LRE1 ( LRE 1;LRE-1;RU-0204277;RU 0204277 )

产品货号. M11791 CAS No. 1424605-11-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

LRE1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A novel potent, specific and allosteric soluble adenylyl cyclase (sAC) inhibitor with IC50 of 3.3 uM in RF-MSS assays.
产品描述

A novel potent, specific and allosteric soluble adenylyl cyclase (sAC) inhibitor with IC50 of 3.3 uM in RF-MSS assays; does not inhibit other transmembrane adenylyl cyclases (tmACs) indluding tmACs I, II, V, VIII and IX at 50 uM; binds to the bicarbonate activator binding site and inhibited sAC via a unique allosteric mechanism; inhibits cAMP accumulation in 4-4 cells with an IC50 of 11 uM, and is non-toxic and does not uncouple mitochondria.
同义词

LRE 1;LRE-1;RU-0204277;RU 0204277
通路

Metabolic Enzyme/Protease
靶点

Adenylate Cyclase
受体

Adenylate Cyclase
研究领域

——
适应症

——

1. Ramos-Espiritu L, et al. Nat Chem Biol. 2016 Oct;12(10):838-44.

计算器

产品手册

关联产品

Small Cardioactive P...

Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.
TIP 39, Tuberoinfund...

This is a tuberoinfundibular neuropeptide and parathyroid hormone 2(PTH 2)-receptor agonist from hypothalmus. Synthetic TIP39 activates human and rat PTH2 receptors.
TIP 39, Tuberoinfund...

This is a tuberoinfundibular neuropeptide and parathyroid hormone 2(PTH 2)-receptor agonist from hypothalmus. Synthetic TIP39 activates human and rat PTH2 receptors.