LOC14
CAS No. 877963-94-5
LOC14 ( —— )
产品货号. M20192 CAS No. 877963-94-5
LOC14 是迄今为止报道的最有效的 PDI 抑制剂(EC50:500 nM)。
纯度: >98% (HPLC)
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥348 | 有现货 |
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10MG | ¥656 | 有现货 |
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25MG | ¥1385 | 有现货 |
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50MG | ¥2511 | 有现货 |
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100MG | ¥4398 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称LOC14
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述LOC14 是迄今为止报道的最有效的 PDI 抑制剂(EC50:500 nM)。
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产品描述LOC14 to be the most potent PDI inhibitor reported to date( EC50 : 500 nM).
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体外实验Cell Viability Assay Cell Line:MTEC cells Concentration:0.01 μM; 0.1 μM; 0.5 μM; 1 μM; 5 μM; 10 μM; 100 μM Incubation Time:24 hours Result:Inhibited recombinant (r)PDIA3 activity.
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体内实验Animal Model:Male N171–82Q HD mice Dosage:20 mg/kg Administration:Orally administered by gavage; 20 mg/kg; once daily; 12-28 weeks Result:Improved motor function in HD mice.
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同义词——
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通路Others
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靶点Other Targets
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受体PDI
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研究领域——
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适应症——
化学信息
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CAS Number877963-94-5
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分子量317.4
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分子式C16H19N3O2S
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纯度>98% (HPLC)
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溶解度DMSO:25 mg/mL?(78.76 mM)
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SMILESO=C(C1CC1)N1CCN(Cn2sc3ccccc3c2=O)CC1
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化学全称2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-12-benzisothiazol-3(2H)-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Heliotrine N-oxide
Heliotrine N-oxide is the pyrrolizidine alkaloid (PA) N-oxide counterpart of Heliotrine. It induces the generation of pyrrolic DNA adducts, potentially initiating PA-induced liver tumors in vivo.
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KHK-IN-1
KHK-IN-1 是一种可逆的 ATP 竞争性酮己糖激酶 (KHK) 抑制剂,IC50 为 12 nM。在 KHK 的 ATP 结合区域中,KHK-IN-1 与 Asp-27B 相互作用。
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[Sar1, Ile8]-Angiote...
[Sar1, Ile8]-Angiotensin II is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels. The biological activities of angiotensin II antagonists upon basal and angiotensin II-stimulated aldosterone production were evaluated in an isolated canine glomerulosa cell preparation.