LMTK3-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LMTK3-IN-1 (compound C28) 是狐猴酪氨酸激酶 3 (LMTK3) (Kd=2.5 μM) 的 ATP 竞争性抑制剂，通过泛素蛋白酶体途径降解 LMTK3 发挥作用。LMTK3-IN-1 在多种癌细胞系和体内 BC 小鼠模型中显示出抗癌活性。10-20 μM LMTK3-IN-1 可诱导 BC 细胞系凋亡。

LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM.

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Angiogenesis

c-Met/HGFR

c-Met/HGFR

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2764850-23-7

356.3

C18H11F3N4O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 5 mg/mL (14.03 mM; 超声助溶 (<60°C)

FC(F)(F)OC1=CC=CC(=C1)C2=CN=C3C=CC(=NN32)C=4C=CN=CC4

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(-20℃)

With Ice Pack

≥ 2 years