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LM22A-4
CAS No. 37988-18-4
LM22A-4 ( —— )
产品货号. M20852 CAS No. 37988-18-4
LM22A-4 是一种脑源性神经营养因子 (BDNF) 模拟物和受体原肌球蛋白相关激酶 B（TrkB；荧光各向异性测定中的 IC50：47 nM）的激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥316 | 有现货 |
|
| 10MG | ￥583 | 有现货 |
|
| 25MG | ￥1256 | 有现货 |
|
| 50MG | ￥2203 | 有现货 |
|
| 100MG | ￥3872 | 有现货 |
|
| 500MG | ￥8505 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称LM22A-4
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述LM22A-4 是一种脑源性神经营养因子 (BDNF) 模拟物和受体原肌球蛋白相关激酶 B（TrkB；荧光各向异性测定中的 IC50：47 nM）的激动剂。
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产品描述LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB;?IC50 : 47 nM in a fluorescence anisotropy assay).
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体外实验LM22A-4 significantly up-regulates OPN and ALPase mRNA expression in a dose-dependent manner and OC mRNA level is significantly increased by 5 μM of LM22A-4. LM22A-4 significantly increases OPN, ALPase and OC mRNA expression in a time-dependent manner. LM22A-4 stimulated OPN and OC mRNA expression in HCEM cells cultured with mineralizing media.
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体内实验LM22A-4 (10 mg/kg, i.p.) significantly reduces the degree of tissue injury and apoptosis (TUNEL staining and caspase-3 and Bcl-2 expression) compared with vehicle treated group. LM22A-4 also significantly ameliorates the recovery of limb function. LM22A-4 (10 mg/kg) treatment results in a significant increase in neuron number. LM22A-4 administration (10 mg/kg) significantly improves the neurological scores compared with those of the solvent-treated animals.
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同义词——
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通路Tyrosine Kinase
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靶点Trk Receptor
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受体Trk
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研究领域——
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适应症——
化学信息
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CAS Number37988-18-4
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分子量339.34
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分子式C15H21N3O6
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纯度>98% (HPLC)
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溶解度H2O:50 mg/mL (147.34 mM);DMSO:29 mg/mL (85.46 mM)
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SMILESO=C(NCCO)c1cc(C(=O)NCCO)cc(C(=O)NCCO)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Schmid D A Yang T Ogier M et al. A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome[J]. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 2012 32(5):1803-1810.
产品手册
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