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LDC000067

CAS No. 1073485-20-7

LDC000067 ( LDC000067; LDC-000067; LDC 000067 )

产品货号. M17138 CAS No. 1073485-20-7

LDC000067 is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.

纯度: 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥308 有现货
5MG ¥389 有现货
10MG ¥705 有现货
25MG ¥1401 有现货
50MG ¥2074 有现货
100MG ¥3070 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    LDC000067
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    LDC000067 is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.
  • 产品描述
    LDC000067 is a potent and selective CDK9 inhibitor. LDC000067 inhibited in vitro transcription in an ATP-competitive and dose-dependent manner. Gene expression profiling of cells treated with LDC000067 demonstrated a selective reduction of short-lived mRNAs, including important regulators of proliferation and apoptosis. Analysis of de novoRNA synthesis suggested a wide ranging positive role of CDK9. At the molecular and cellular level, LDC000067 reproduced effects characteristic of CDK9 inhibition such as enhanced pausing of RNA polymerase II on genes and, most importantly, induction of apoptosis in cancer cells.
  • 同义词
    LDC000067; LDC-000067; LDC 000067
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    CDK1; CDK2; CDK4; CDK6; CDK9
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1073485-20-7
  • 分子量
    370.43
  • 分子式
    C18H18N4O3S
  • 纯度
    98%
  • 溶解度
    DMSO : ≥ 47 mg/mL 126.88 mM
  • SMILES
    COc1ccccc1c1cc(ncn1)Nc1cccc(c1)CS(=O)(=O)N
  • 化学全称
    6-(6-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylthio)quinoline

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Albert TK, et al. Br J Pharmacol. 2014, 171(1), 55-68.
产品手册
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