LB42708 ( LB42708; LB-42708; LB 42708 )

产品货号. M17445 CAS No. 226929-39-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

LB42708
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).
产品描述

LB42708 is a potent, orally active and selective nonpeptidic farnesyltransferase inhibitor (FTase inhibitor). LB42708 inhibited VEGF-induced Ras activation and subsequently suppressed angiogenesis in vitro and in vivo by blocking the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric-oxide synthase pathways in endothelial cells without altering FAK/Src activation.
同义词

LB42708; LB-42708; LB 42708
通路

Others
靶点

Other Targets
受体

Farnesyl transferase (FTase); Farnesyl transferase (FTase); Farnesyl transferase (FTase)
研究领域

Cancer
适应症

——

CAS Number

226929-39-1
分子量

555.46
分子式

C30H27BrN4O2
纯度

98%
溶解度

——
SMILES

Brc1ccc(Cn2cncc2Cn2cc(C(=O)N3CCOCC3)c(c2)c2cccc3ccccc23)cc1
化学全称

(1-((1-(4-bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone

1. Na HJ, et al. J Immunol. 2004, 173(2), 1276-1283.

计算器

产品手册

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