021-51111890
购物车（）
sales@molnova.cn
L524-0366
CAS No. 951612-19-4
L524-0366 ( [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone )
产品货号. M22217 CAS No. 951612-19-4
L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1604 | 有现货 |
|
| 5MG | ￥2406 | 有现货 |
|
| 10MG | ￥3669 | 有现货 |
|
| 25MG | ￥6229 | 有现货 |
|
| 50MG | ￥8060 | 有现货 |
|
| 100MG | ￥11745 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称L524-0366
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.
-
产品描述L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling. Finally, Fn14 expression was increased in mouse following TAC and in human failing hearts.
-
同义词[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
-
通路Others
-
靶点Other Targets
-
受体Fn14
-
研究领域——
-
适应症——
化学信息
-
CAS Number951612-19-4
-
分子量308.79
-
分子式C13H13ClN4OS
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESO=C(C1=CN(C2=CC=CC(Cl)=C2)N=N1)N3CCSCC3
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Unudurthi S D , Nassal D M , Patel N J , et al. Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction[J]. Life ences, 2020, 247:117440.
产品手册
关联产品
-
Methyl nomilinate
Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
-
Benzyl beta-D-glucop...
Benzyl β-D-glucopyranoside is a natural product for research related to life sciences.
-
Bractoppin
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro.
