L524-0366
CAS No. 951612-19-4
L524-0366 ( [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone )
产品货号. M22217 CAS No. 951612-19-4
L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1604 | 有现货 |
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5MG | ¥2406 | 有现货 |
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10MG | ¥3669 | 有现货 |
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25MG | ¥6229 | 有现货 |
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50MG | ¥8060 | 有现货 |
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100MG | ¥11745 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称L524-0366
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.
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产品描述L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling. Finally, Fn14 expression was increased in mouse following TAC and in human failing hearts.
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同义词[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
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通路Others
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靶点Other Targets
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受体Fn14
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研究领域——
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适应症——
化学信息
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CAS Number951612-19-4
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分子量308.79
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分子式C13H13ClN4OS
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1=CN(C2=CC=CC(Cl)=C2)N=N1)N3CCSCC3
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Unudurthi S D , Nassal D M , Patel N J , et al. Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction[J]. Life ences, 2020, 247:117440.
产品手册
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