L-689560

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

L-689560 广泛用作结合研究中的放射性标记配体，并用于研究 NMDA 受体在正常神经过程以及疾病中的作用。

L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in diseases. At the GluN1 glycine binding site, L-689560 is an effective N-methyl-D-aspartate (NMDA) receptor antagonist.(In Vitro):The specific NMDA/glycine site blocker L-689560 (0.1–20 μm) impaired swimming rhythm generation and abolished NMDA-induced locomotor-like ventral root activity. d-serine (50 μm), an agonist at the NMDA/glycine site, increased the duration of skin stimulus-induced fictive swimming episodes, and produced slow modulations of burst frequency and amplitude. These effects of d-serine were reversed by L-689560.(In Vivo):L-689560 blocks the glycine-induced increase of Akt phosphorylation in the MCAO model. L-689560 (1?mg/kg, ip) obviously decreases the neuroprotective effect of glycine after glycine receptors, and the channel activity of NMDA receptors (NMDARs) are suppressed .

L-689560 is a 2-carboxytetrahydroquinoline antagonist.

L-689560 (1?mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model Animal Model:Adult male Sprague-Dawley (SD) rats middle cerebral artery occlusion (MCAO) modelDosage:1?mg/kg Administration:IPResult:Significantly reduced the neuroprotective effect of glycine after glycine receptors.

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Membrane Transporter/Ion Channel

NMDAR

5-LOX| COX-1| COX-2

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139051-78-8

380.23

C17H15Cl2N3O3

>98% (HPLC)

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OC(=O)[C@H]1C[C@H](NC(=O)Nc2ccccc2)c2c(Cl)cc(Cl)cc2N1

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(-20℃)

With Ice Pack

≥ 2 years