Kurarinone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

苦参酮（Kurarinone）是一种从灌木苦参中提取的黄酮类化合物，苦参酮具有抗肿瘤、雌激素和抗炎活性，对免疫反应也表现出强烈的抑制作用。 Kurarinone 可通过抑制致病性 CD4(+) T 细胞分化和整体免疫反应来改善慢性炎症性皮肤病。

Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses.?Kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4(+) T-cell differentiation and the overall immune response.Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. METHODS AND RESULTS:Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, Kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay.

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Others

Other Targets

Others

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34981-26-5

438.52

C26H30O6

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (114.02 mM)

O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=C(C[C@H](C(C)=C)C/C=C(C)\C)C(O)=CC(OC)=C13

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(-20℃)

With Ice Pack

≥ 2 years