Kuraridine ( —— )

产品货号. M31175 CAS No. 34981-25-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Kuraridine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.
产品描述

Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.
体外实验

Kuraridine shows potent inhibitory activity (IC50=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively.Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal?IGABA?induced by a saturating GABA concentration (1 mM).Kuraridine induces a concentration–response curves for?IGABA?enhancement (EC50=4.0±2.4 μM) in Xenopus?oocytes expressing GABAA?receptors composed of?α1, β2, and?γ2S?subunits.
体内实验

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受体

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研究领域

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适应症

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