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Koumine
CAS No. 1358-76-5
Koumine ( Koumine )
产品货号. M17971 CAS No. 1358-76-5
Koumine具有抗肿瘤作用,可能成为未来乳腺癌的化疗剂。
纯度: >98% (HPLC)
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规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1746 | 有现货 |
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100MG | 获取报价 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Koumine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Koumine具有抗肿瘤作用,可能成为未来乳腺癌的化疗剂。
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产品描述Koumine is an indole alkaloid. It reverses thermal hyperalgesia and mechanical allodynia induced by sciatic nerve chronic constriction injury (CCI) in rats in a dose-dependent manner. This effect is mediated by elevated allopregnanolone levels in the spinal cord.
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体外实验Koumine (0.5, 1 and 2 mg/mL) dose- and time-dependently inhibits the proliferation of MCF-7 cells, with an IC50 of 124 μg/mL at 72 h. Koumine induces apoptosis, causes cell cycle arrest at G2/M phase. Koumine (0.5, 1 and 2 mg/mL) up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in a dose-dependent manner in MCF-7 Cells.Koumine (25, 50, 100, and 200?μM) decreases the protein and mRNA levels of microglia M1 polarization factors in LPS-induced BV2 cells.
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体内实验Koumine is less toxic, with the median lethal dose (LD50) of 300.0 mg/kg on Wistar rats. Koumine (0.6, 3, or 15 mg/kg/per, p.o.) exhibits antirheumatic properties in rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA).Koumine inhibits the increase in cytokines in joint tissue and TNF-α level in serum at 15 mg/kg, and suppresses the increase in the serum level of IL-1β at 3 and 15 mg/kg.Koumine (0.28, 7 mg/kg, s.c.) significantly reduces neuropathic pain after nerve injury. Koumine suppresses the increased Iba-1 protein level.
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同义词Koumine
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通路Others
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靶点Other Targets
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受体Others
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研究领域Others-Field
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适应症——
化学信息
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CAS Number1358-76-5
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分子量306.4
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分子式C20H22N2O
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纯度>98% (HPLC)
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溶解度DMSO : 31.25 mg/mL 101.99 mM;
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SMILESCN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C
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化学全称(4aR,6R,11cS)-2-methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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