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Koumine

CAS No. 1358-76-5

Koumine ( Koumine )

产品货号. M17971 CAS No. 1358-76-5

Koumine具有抗肿瘤作用,可能成为未来乳腺癌的化疗剂。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1746 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Koumine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Koumine具有抗肿瘤作用,可能成为未来乳腺癌的化疗剂。
  • 产品描述
    Koumine is an indole alkaloid. It reverses thermal hyperalgesia and mechanical allodynia induced by sciatic nerve chronic constriction injury (CCI) in rats in a dose-dependent manner. This effect is mediated by elevated allopregnanolone levels in the spinal cord.
  • 体外实验
    Koumine (0.5, 1 and 2 mg/mL) dose- and time-dependently inhibits the proliferation of MCF-7 cells, with an IC50 of 124 μg/mL at 72 h. Koumine induces apoptosis, causes cell cycle arrest at G2/M phase. Koumine (0.5, 1 and 2 mg/mL) up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in a dose-dependent manner in MCF-7 Cells.Koumine (25, 50, 100, and 200?μM) decreases the protein and mRNA levels of microglia M1 polarization factors in LPS-induced BV2 cells.
  • 体内实验
    Koumine is less toxic, with the median lethal dose (LD50) of 300.0 mg/kg on Wistar rats. Koumine (0.6, 3, or 15 mg/kg/per, p.o.) exhibits antirheumatic properties in rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA).Koumine inhibits the increase in cytokines in joint tissue and TNF-α level in serum at 15 mg/kg, and suppresses the increase in the serum level of IL-1β at 3 and 15 mg/kg.Koumine (0.28, 7 mg/kg, s.c.) significantly reduces neuropathic pain after nerve injury. Koumine suppresses the increased Iba-1 protein level.
  • 同义词
    Koumine
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Others-Field
  • 适应症
    ——

化学信息

  • CAS Number
    1358-76-5
  • 分子量
    306.4
  • 分子式
    C20H22N2O
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 31.25 mg/mL 101.99 mM;
  • SMILES
    CN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C
  • 化学全称
    (4aR,6R,11cS)-2-methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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