Kinetin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

激动素是细胞分裂素的一种，是一类促进细胞分裂的植物激素。

Kinetin is a type of cytokinin, a class of plant hormone that promotes cell division.(In Vitro):Kinetin (N6-furfuryladenine) shows to have a direct effect on superoxide dismutase activity in plants; prevent oxidation of unsaturated acids in plant membranes; slow down development and aging in insects, by reducing their fecundity and increasing the specific activity of catalase; and delay the onset of many age-related characteristics that appear in normal human skin fibroblasts undergoing aging in vitro. Kinetin (70-150 μM) markedly suppressed hydroxyl radical formation by about 41% and 76%, respectively.The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured familial dysautonomia (FD) cells.(In Vivo):Kinetin (N6-furfuryladenine) (2-6 mg/kg; injection into the tail vein) effectively prevents ADP-induced acute pulmonary thrombosis in mice.Subjects received 23.5 mg/kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant.

Kinetin (N6-furfuryladenine) shows to have a direct effect on superoxide dismutase activity in plants; prevent oxidation of unsaturated acids in plant membranes; slow down development and aging in insects, by reducing their fecundity and increasing the specific activity of catalase; and delay the onset of many age-related characteristics that appear in normal human skin fibroblasts undergoing aging in vitro. Kinetin (70-150 μM) markedly suppressed hydroxyl radical formation by about 41% and 76%, respectively. The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured familial dysautonomia (FD) cells.

Kinetin (N6-furfuryladenine) (2-6 mg/kg; injection into the tail vein) effectively prevents ADP-induced acute pulmonary thrombosis in mice.Subjects received 23.5 mg/kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant. Animal Model:ADP-induced acute pulmonary thrombosis 20-24 g mice (ICR strain) Dosage:2, 4, 6 mg/kg Administration:Injection into the tail vein Result:Reduced mortality to 70%, 40% and 35% at 2, 4, and 6 mg/kg, respectively.

N6-furfuryladenine | NSC 23119

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Other Indications

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525-79-1

215.21

C10H9N5O

>98% (HPLC)

DMSO: 8 mg/mL warmed (37.17 mM)

9H-Purin-6-amine, N-(2-furanylmethyl)-

9H-Purin-6-amine, N-(2-furanylmethyl)-

(-20℃)

With Ice Pack

≥ 2 years