
Ki16198
CAS No. 355025-13-7
Ki16198 ( —— )
产品货号. M19446 CAS No. 355025-13-7
Ki16198 是 Ki16425 的甲酯,Ki16425 是一种 LPA 拮抗剂,可抑制 LPA1 和 LPA3 诱导的磷酸肌醇产生,Ki 分别为 0.34 μM 和 0.93 μM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥648 | 有现货 |
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10MG | ¥1126 | 有现货 |
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25MG | ¥2341 | 有现货 |
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50MG | ¥3686 | 有现货 |
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100MG | ¥5443 | 有现货 |
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500MG | ¥11583 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Ki16198
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Ki16198 是 Ki16425 的甲酯,Ki16425 是一种 LPA 拮抗剂,可抑制 LPA1 和 LPA3 诱导的磷酸肌醇产生,Ki 分别为 0.34 μM 和 0.93 μM。
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产品描述Ki16198 is the methyl ester of Ki16425 which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM respectively shows weaker inhibition for LPA2 no activity at LPA4 LPA5 LPA6.
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体外实验Ki16198 (0-10 μM; 48 hours) is effective to inhibit migration and invasion responses to LPA with a potency similar to that of Ki16425. The inhibitory effects Ki16198 on the invasion response to LPA, but not to EGF in several pancreatic cancer cell lines, including Panc-1,CFPAC-1, and BxPC-3 cells.Ki16198 (10 μM; 48 hours) signifivcantly decreases expression of proMMP-9 protein and mRNA expression in YAPC-PD cells.
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体内实验Ki16198 (oral administaion; 1 mg in 500 ul; 28 days) significantly decreases the degree of metastasis activity in Ki16198-treated mice. Similiar to liver, metastasis to lung and brain in mice is also observed. Animal Model:Male BALB/c nude mice (6 weeks old) Dosage:1 mg in 500 ul Administration:Oral administaion; 28 days Result:Inhibited lung and liver metastasis in vivo.
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同义词——
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通路GPCR/G Protein
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靶点LPA Receptor
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受体LPA1 LPA3
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研究领域Cancer
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适应症Cancer
化学信息
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CAS Number355025-13-7
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分子量488.98
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分子式C24H25ClN2O5S
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纯度>98% (HPLC)
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溶解度DMSO:89 mg/mL (182 mM);Ethanol:33 mg/mL (67.5 mM);Water:<1 mg/mL
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SMILESCOC(=O)CCSCC1=CC=C(C=C1)C1=C(NC(=O)OC(C)C2=C(Cl)C=CC=C2)C(C)=NO1
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化学全称3-(4-(4-((1-(2-Chlorophenyl)ethoxy)carbonylamino)-3-methyl-5-isoxazolyl)benzylsulfanyl)propanoic acid methyl ester
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Komachi M et al. Cancer Sci 2012 103(6) 1099-1104.
产品手册




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