Karanjin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Karanjin 是从 karanja 树种子中提取的黄酮类化合物。Karanjin 通过增加 AMPK 活性来诱导骨骼肌细胞中的 GLUT4 易位。

Karanjin is a flavonoid?obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity.?Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis.

Cell Cycle Analysis Cell Line:A549, HL-60 Concentration:4, 6, 8 μM for A549, 2, 4, 6 μM for HL-60 Incubation Time:72 h Result:Blocked the cell cycle markedly at G2/M phase of A549 (>60% for 8 μM) and HL-60 (>40% for 6 μM)

Animal Model:Streptozotocin-induced diabetic ratsDosage:50, 100 mg/kg Administration:Oral gavage (p.o.), wait for 6hResult:Lowered the blood glucose level by 11.7% and 20.7% at 50 and 100 mg/kg gavage.Animal Model:Adjuvant induced arthritis model (AIA) Wistar strain male albino rats Dosage:10, 20 mg/kg/d Administration:Oral gavage (p.o.), 14 d for serum assay, 21 d for histological examinationResult:Reduced articular cartilage damage, cellular infiltration in the articular cartilage and spongy bone damage significantly. Decreased serum acid phosphatase, alkaline phosphatase levels and TNFα level markedly.Animal Model:Diazepam-induced male swiss albino mice Dosage:25, 50 mg/kg/d Administration:Oral gavage (p.o.) or Intraperitoneal injection (i.p.) for 8 d Result:Decreased the transfer latency on all the observation days, significantly reversed diazepam-induced amnesia, indicating improved learning and memory in treated mice.

——

Membrane Transporter/Ion Channel

AMPK

AMPK

——

——

521-88-0

292.29

C18H12O4

>98% (HPLC)

DMSO:10 mM

O=C1C(OC)=C(C2=CC=CC=C2)OC3=C1C=CC4=C3C=CO4

——

(-20℃)

With Ice Pack

≥ 2 years