KYN-101

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KYN-101 是一种有效的、选择性的和具有口服活性的 AHR 抑制剂。KYN-101 降低 CYP1A1 mRNA 表达。KYN-101 具有抗癌活性。

KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity.

——

Animal Model:6-8 weeks, C57BL/6J mice (B16IDO tumor-bearing mice)Dosage:10 mg/kg Administration:P.o.; daily for 12 days Result:Reduced tumor growth in B16IDO tumor-bearing mice and combination of KYN-101 and anti-PD-1 led to improved tumor growth delay and extended survival in CT26 models.

——

Endocrinology/Hormones

AhR

AhR

——

——

2247950-73-6

386.43

C22H19FN6

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (258.79 mM; 超声助溶 )

FC1=CN=CC(=C1)C2=NC3=C(C=NN3C(=C2)NCCC4=CNC=5C=CC=CC54)C

——

(-20℃)

With Ice Pack

≥ 2 years