KL201

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues.

KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues.(In Vitro):KL201 causes dose-dependent lengthening of circadian period in Bmal1-dLuc reporter cells, and in cells with another circadian reporter Per2-dLuc. KL201 suppresses the intensity of Per2-dLuc reporter much more than that of Bmal1-dLuc, without affecting cellular viability. KL201 binds to CRY1 in overlap with FBXL3, a subunit of ubiquitin ligase complex, and the effect of KL201 is blunted by knockdown of FBXL3. KL201 lengthened circadian period and suppressed the intensity of Per2::Luc knockin reporter in mouse lung primary explants.

——

Others

Other Targets

hLPA5

——

——

302939-48-6

388.3

C17H14BrN3OS

>98% (HPLC)

——

Brc1ccccc1C(=O)Nc1ncnc2sc3CCCCc3c12

——

(-20℃)

With Ice Pack

≥ 2 years