KL-50 ( ——— )

产品货号. M39442 CAS No. 1161826-19-2

KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
25MG	￥11904	有现货
50MG	获取报价	有现货
100MG	获取报价	有现货

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生物学信息

产品名称

KL-50
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions.
产品描述

KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT.
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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化学信息

CAS Number

1161826-19-2
分子量

226.17
分子式

C7H7FN6O2
纯度

>98% (HPLC)
溶解度

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SMILES

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化学全称

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运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Huseman ED, et al. Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. J Am Chem Soc. 2024 Jul 10;146(27):18241-18252.?

计算器

浓度计算器

摩尔计算器

分子量计算器

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